The NIHR’s 2024/25 annual report highlights its significant impact on health and the economy, supporting the government’s 10 Year Health Plan. Key achievements include breakthroughs like the first mRNA immunotherapy for skin cancer and advances in public health. NIHR research returns over £13 in economic benefit for every £1 invested, drives innovation and supports thousands of UK jobs. Increased funding this year strengthened research training, infrastructure and inclusion, helping deliver better care and future-proof the health system.